Nick you sure about that 12volts?
The MCLR pin on the PIC will be driven to approximately 13V during programming. This raises two concerns. The first is that your circuit must allow 13V on the pin. Don't connect the pin directly to the Vdd rail. The second concern is that the rest of your circuit may need to be protected from this voltage. If 13V on the MCLR pin might put at risk other components on your board, use a diode in series with the RESET pullup to keep the 13V off of the Vdd line.
Pin out and suggestions
http://picbasic.com/support/icsp.htm





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