The MeProg has a menu selection for this. Under Options, the first one (in my version) is Update Configuration From File. If you check this, then the file takes precedence; if not, then the programmer configs do. What I often do for testing purposes is set the fuses in the code, and turn this on before you open the file to program--that makes the programmer accept those PBP config settings. Then, turn off the menu item, make adjustments if necessary, then program.
I always put it back on before closing the program...that way I don't forget it next time and wonder why my 18F configs are set to default again (typically that's what happens when you switch from different PIC types) or all out of whack (what happens when you have two projects with different configs).
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