Thank you Mike and Jerson. To explain in more detail, I'll try to answer your questions as best I can.

The mcu I plan on using is the 16F871.

On port B, I'll have 8 dip switches for the "board" address (set high or low).
0 to 256 ex: B129

There will be 24 GPIO's left over, therefore they will be the "relay".
1 to 24 ex: R22

The "stat" will either be on or off.
0 or 1 ex: S0

In the above example, I would like to:
On board 129, turn relay 22 off

On that note, I commented 2 lines in the code to possibly garner advice on the proper way to send those commands from vb.net. If any of you could comment on that as well, that would be great.
Thank you guys again.

Chris