Nothing wrong that I can, but I think I would make another +5v line run from your regulator up the left side of the board to make a complete loop instead of a half a loop. The way you've got it right now, whatever is at the 'end' of your 5v run will probably pick up a lot of noise, and if it draws any sort of load, it'll really put spikes on the run going back towards the PIC. Might mess it up.
Maybe a 'sprinkling' of .1uf cap's across +5v and ground here and there, if you can fit an extras in there, might not be a bad idea, even if they're surface mount and you have to solder them across the traces themselves. I've done that a few times just as a precaution, used 0805 sized, just laid them right there, no marking or anythiing, just added them in...
And I think it looks much better without all those 90 degree angles in there...





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