My earlier statement about a 470 from MCLR to VDD is not quite correct for this chip. I have not used this one and after looking at the data sheet for it things are just a little different. VDD does go to MCLR but MCLR on this chip can also be used as an INPUT and has some different characteristics.

If I am looking at your board layout correctly, you may want to look at page 34 of the data sheet. I see MCLR going straight to VDD on your board. Do not know if this is the problem and I am getting a little fuzzy. Been up for 48hrs.