Transmitter will continue to Tx until Vin goes High?
what you have is a lora long distance two way packet radio system that transmits the entire device state each time any input pin changes
to paired receiver constrained by the tx transmission time, that time is between 55 and 1002 mS depending on mode.
its not some cheap OOK thing

5V Tolerant is and means 5v tolerant , it would the least of you problem here