Short answer is yes. For awhile I was using my Mac for programming with Virtual Machine. My wife uses Wine, but I never tried PBP on it. I have no idea if it will work with Linux.

My experience was that is was extremely slow. My Mac is about 7-8 years old, but with the memory maxed out (replaced chips). Not only was I running PBP, but also Virtual Studio and some other memory hogs. I finally broke down & bought a used Dell for development work. PBP isn't the only software I use that only works with Windows.