mpgmike, I got the sensor to respond to my finger temp difference. Here is the code so far:

Yes, yes, I am prototyping on a Stamp :/

Code:
' {$STAMP BS2p}
' {$PBASIC 2.0}

  tf    VAR Byte
  tc    VAR Byte
  rawT  VAR Word
  rawRH VAR Byte

  PAUSE 250                                     ' let DEBUG window open
  DEBUG CLS
  DEBUG "SHT21 Demo", CR
  DEBUG "----------", CR

Main:

I2COUT 0 ,%10000000, [%11100011]
  PAUSE 50
I2CIN  1 , %10000001, [rawT]
  DEBUG 2, 0, 3
  DEBUG "rawT...... "
  DEBUG  DEC rawT, 11, CR
  rawT= rawT <<2
  tC = (rawT & $fffc) ** 17572 - 4685
  DEBUG "Deg C......", DEC tC
  PAUSE 500


  GOTO main
Getting elevated readings on the SHT21
The SHT21 temp says my room is 42°C (107.6°F) Actual temperature is ~ 23.8°C (75°F)
rawT @ 42°C = 111