I2C has 2 variants I2Cmaster and I2Cslave. The master always is in command and the slave responds to the master initiated query/commands.

SPI usually has 4 wires MISO, MOSI, SCLK, CS (Master In Slave Out, Master out slave In, serial clock, chip select). Some devices may signal availability of data on the MISO line when the CS is held inactive. That is implementation specific to that device.

An interrupt line has no relation to the 2 protocols except you might be able to enable / disable the feature via the communications by setting of some register