Hi,
When there's no power applied to the Vdd rail of the uC driving its pins may result in the protective diode between the input and Vdd to conduct and start "feeding" the uC internally so to speak. You have 64k in series with that possible "feed" so it's unlikely it will actually work but it might try to start up and that can perhaps make it do some weird things. I'd proably turn off power to any circuitry that's interfaces TO the uC as well as the uC itself.
EDIT: On a second look I see that you have the output the AD620 directly connected to a pin on the uC, if it can supply enough current then you could be in trouble.
/Henrik.
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