Only if you use PBPL instead of PBPW then yes. You can make e.g. comparisons for negative numbers.

Code:
Bval VAR BYTE
Bval = 0
IF ((Bval – 1) < 0) THEN negative
In the abobe example although Bval is byte, internally the PBPL holds the temporary result in a long variable which in turn can hold negative numbers too.

So the result of the IF-THEN will goto negative.

Ioannis