What are you trying to do? What are you "driving" with the PIC?
PICs are actually quite rugged. You can't really blow them up solely by writing "bad" code, there must be some hardware problem which, perhaps in conjunction with bad code, destroys them. (Like having two outputs tied together and driving one high and the other low (not sure that would actually destroy it either but it's not good))

I've played with these things for ~15 years and I honestly can't remember ever destroying one except when I accidently powered one with 24V.

If you're doing high power stuff (like the ever so popular 3-phase inverter stuff) you really need to get the hardware and PCB layout correct.

Proteus might show if the code works or not but I don't think it'll "destroy" the PIC in case there's a designflaw in the hardware causing intermittent problems.