Hi,
I'm not following you on the resolution. You say the transducer measures 0-100000 PSI with a resolution of 0.0001 PSI? That's 1.000.000.000 "counts" across the 16mA output swing - WOW!

I mean, even at 1 PSI "per count" the difference in output current is 0.016/100000=0.16uA. Push that thru your 250ohm resistor and you get a voltage change of 40uV per PSI - that's not a lot.

If you mean 100PSI then it gets a little more managable as 1PSI now eqauls a change in current of 160uA and a voltage change across the resistor of 40mV.

/Henrik.