Shouldn't be a problem...
Michael, I've had no problems overwriting data displayed on an LCD. It's not necessary to clear everything. And as for clearing an entire line, would it work for you to send a line of ASCII space characters? That would display a blank line. It's always good practice to clear the display when you first power it up with a "$FE,1". As for multiple LCD's on one PIC, there's been some discussion here. It's not as simple as you think. You should be able to search for those threads.