If you are installing from the blue disc, you shouldn't have any problems.
But remember to right-click the install program and "Run As Administrator".
If you are installing from an older Black and White disc, there are a few extra steps to follow.
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Re: BME280 via I2C?
I've worked with the BMP180 with PBP, but not the BME280 IIRC.
rocket_troy Today, 00:35Troy