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There are lots of better text editors out there, like notepad++ https://notepad-plus-plus.org/ and it's free.

For that matter, the MPLAB editor can open multiple source files (ie multiple windows)...

If that's all you want to do then any text editor would work (ie Notepad)

For this to work I think you need to have one-to-one project-workspace enabled (MPLAB main menu Configure | Settings... | Projects | Use one-to-one project-workspace model).

It's of limited use...

Yes, you can. I have three instances running right now.
Just launch it from an mplab project (.mcp file) and not a generic shortcut.


It IS easy to get it confused. I prefer to use different...

Do you get an error message or a warning?

I've done it in the past. I think you need to have different workspaces and different debugger tools (ie PK3 and ICD3) from what I remember.